RT Book, Section A1 Murtagh, John A1 Murtagh, Clare SR Print(0) ID 1201939597 T1 M T2 John Murtagh’s General Practice Companion Handbook, 8th Edition YR 2022 FD 2022 PB McGraw-Hill Education (Australia) Pty Ltd PP Sydney, Australia SN 9781743768266 LK murtagh.mhmedical.com/content.aspx?aid=1201939597 RD 2024/04/24 AB Early diagnosis is vital to outcome. Thickness of a melanoma when it is removed is the major factor determining prognosis: it is vital to detect melanomas when they are in the thin stage and look like an unusual freckle. An irregular border or margin is characteristic of the tumour.