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INTRODUCTION

Apart from migraine, virtually all cases of sudden loss of vision require urgent treatment.

IMPORTANT CAUSES

Amblyopia

In children, a lazy eye with reduced vision. Consider large refractive defect and congenital cataract. Refer strabismus early.

Retinoblastoma

In children: white pupil and ‘cat’s eye’ reflex. An intra-ocular tumour, dominant gene.

Cataracts

  • Reduced visual acuity (sometimes improved with pinhole)

  • Diminished red reflex on ophthalmoscopy

  • A change in the appearance of the lens

Advise extraction when the patient cannot cope.

Glaucoma

Acute—rapid onset over a few days

Chronic—gradual loss of outer fields of vision

Tonometry: 22 mmHg is upper limit of normal

  • Medication (for life) usually selected from:

    • – timolol or betaxolol (beware of asthma) drops bd

    • – latanoprost drops or other prostaglandin analogue, once daily

    • – pilocarpine drops qid

    • – acetazolamide (oral diuretics)

  • Surgery or laser therapy for failed medication

Retinitis pigmentosa

  • Begins as night blindness in children; loss of peripheral vision

  • Ophthalmoscopic examination—irregular patches of dark pigment

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Table V5 Acute and subacute painless loss of vision: diagnostic strategy model

Probability diagnosis

  • Amaurosis fugax

  • Migraine

  • Retinal detachment

  • Acute glaucoma

  • ‘Wet’ macular degeneration

Serious disorders not to be missed

  • Cardiovascular:

    • – central retinal artery occlusion

    • – central retinal vein occlusion

    • – hypertension (complications)

    • – CVA

  • Neoplasia:

    • – intracranial tumour

    • – intra-ocular tumour:

      • primary melanoma

      • retinoblastoma

      • metastases

  • Vitreous haemorrhage

  • AIDS

  • Temporal (giant cell) arteritis

  • Acute glaucoma

  • Benign intracranial hypertension

Pitfalls (often missed)

  • Acute glaucoma

  • Papilloedema

  • Optic neuritis

  • Intra-ocular foreign body

Amaurosis fugax

  • Transient unilateral loss of vision; usually due to embolus from carotid artery

  • Requires investigation, incl. carotid duplex Doppler US

Retinal migraine

This migraine variant may present with symptoms of visual loss. Headache and nausea may be absent.

  • Zigzag lines or lights

  • Multicoloured flashing lights

  • Field defect—unilateral or bilateral

  • Resolution within a few hours

Retinal detachment

  • Sudden onset of floaters or flashes or black spots

  • Vision in one eye becoming worse

  • Immediate referral for sealing of retinal tears

Vitreous haemorrhage

  • Sudden onset of floaters or ‘blobs’ in vision; US aids diagnosis

  • Urgent referral to exclude retinal detachment

  • Surgical vitrectomy for persistent haemorrhage

Central retinal artery occlusion

  • Sudden painless unilateral loss of vision like a ‘curtain descending’

  • Vision not improved with 1 mm pinhole

  • Classic ‘red cherry spot’ at macula

Management Treatment options, but poor evidence:

  • Within ...

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