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A rare complication of influenza, chickenpox and other viral diseases (e.g. Coxsackie virus)
Suspected causal relationship between aspirin salicylates for a febrile illness in children <18 yrs
Rapid development of:
30% fatality rate and significant morbidity
Diagnosis is clinical; treatment is supportive and directed at cerebral oedema
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Recommendation: Avoid aspirin for fever in young children—use paracetamol.