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Table P6 Excessive sweating (hyperhidrosis): diagnostic strategy model (see also FUO)

Probability diagnosis

Common infections, esp. respiratory, other infections (viral, urinary), tension/anxiety, menopause, intense pain

Not to be missed

Severe infection, e.g. tropical, HIV, TB, endocarditis, sepsis

Malignancy, e.g. lymphoma, leukaemia, cerebal, lung

Vasoactive tumours: carcinoid syndrome, phaeochromocytoma

Masquerades

Drugs: e.g. antidepressants, NSAIDs, hormone therapy, caffeine, alcohol, opioid withdrawal, PDE5 inhibitors—tadalafil, etc.

Endocrine—hyperthyroidism, hypoglycaemia, pituitary

Note: Perspiration is usually idiopathic.

Treatment

See also image 72

  • Use an antiperspirant deodorant or aluminium chloride hexahydrate 20% solution or spray (e.g. Driclor) (also good for palms and soles)

  • Reduce caffeine intake

  • Avoid known aggravating factors

  • Consider referral for axillary wedge resection or botulinum toxin if axillary hyperhidrosis

  • Iontophoresis

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