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medroxyprogesterone acetate (‘Depo-Provera’)
Dose: 150 mg by deep IM injection in first 5 days of the menstrual cycle. Same dose is given every 12 wks to maintain contraception.
etonogestrel (Implanon)—a third-generation progestogen
Dose: 68 mg by subdermal implantation for up to 3 yrs.
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The main indication for this form of contraception is the desire for a highly effective method. Advantages are avoiding the side-effects of oestrogen (incl. risk of venous thromboembolism, VTE) and overcoming compliance problems. Main disadvantages are marked menstrual irregularities and with Depo-Provera, delayed return of fertility.