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  • Jaundice is defined as a serum bilirubin level above 19 µmol/L.

  • Clinical jaundice manifests only when the bilirubin exceeds 50 µmol/L.

  • Jaundice is difficult to detect visually below 85 µmol/L if lighting is poor.

  • The most common causes recorded in a general practice population are (in order) viral hepatitis, gallstones, carcinoma of pancreas, cirrhosis, pancreatitis and drugs.

  • Always take a full travel, drug and hepatitis contact history in any patient presenting with jaundice.

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Jaundice (adults): diagnostic strategy model

Key history

  • Associated symptoms (e.g. rash, pruritus, fever, arthralgia, weight loss)

  • Medical history

  • Contact with people with hepatitis or jaundice

  • Overseas travel, family history, drug history, IV drug use, sexual history, occupational history

++ Key examination

  • General inspection including skin for signs of excoriation.

  • The abdominal examination is important with a focus on the liver and spleen.

  • Look for signs of chronic liver disease.

  • Test for hepatitis flap (asterixis) and fetor, which indicate liver failure.

  • Include dipstick urine testing for bilirubin and urobilinogen.

++ Key investigations

  • The main ones are the standard LFTs and viral serology for infective causes (hepatitis A, B, C and possibly EBV).

  • Consider hepatobiliary imaging, autoantibodies for autoimmune chronic active hepatitis and primary biliary cirrhosis, tumour markers and iron studies.

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Characteristic liver function tests

Infective viral hepatitis
++ ++

  • Hepatitis A, B, C, common esp. B and C

  • A and E—faeco–oral transmission

  • B, C, D—from IV drugs and bodily fluids

  • Sexual transmission with B and C

  • Diagnosed by viral markers for A, ...

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